Healthy control mild cognitive impairment Alzheimer’s disease Alzheimer’s disease neuroimaging initiative Mini-Mental State Examination Montreal Cognitive Assessment apolipoprotein E early mild cognitive impairment late mild cognitive impairment. In addition, the measurements of MMSE and MoCA are moderately correlated for the follow-up visits. MMSE and MoCA are comparable as cognitive assessment tools to monitor cognitive changes. 454647 It has shown high sensitivity (82) for detecting cognitive impairment associated with vascular disease or stroke 46 and. At last, the MMSE scores were moderately related to MoCA scores, which got stronger along with the time of follow-up. The TICS performance is comparable with the Telephone MoCA. For participants with a diagnosis of LMCI, the cognitive performance deteriorated in a linear manner 12 months after the baseline, which was independent of MMSE or MoCA. By contrast, the MoCA scores were not significantly different between HC and EMCI groups at either baseline or any of the follow-up visits. The MMSE scores were significantly different among the four groups at baseline, which was true for each of the three annual follow-up visits. For those participants who had both MMSE and MoCA assessments done, a Pearson correlation analysis was performed between the two assessments for each visit. MMSE or MoCA scores were compared among the four groups using an analysis of variance (ANOVA) model with repeated measures with post-hoc Bonferroni correction. Our goal was to assess their efficacy for monitoring cognitive changes, as well as the correlation between the two tests.Īt baseline, participants in the Alzheimer's Disease Neuroimaging Initiative (ADNI) were divided into four groups based on their cognitive diagnoses: healthy control (HC), early mild cognitive impairment (EMCI), late mild cognitive impairment (LMCI), and Alzheimer's disease (AD). Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) are two commonly used cognitive screening and diagnostic tools.
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